ABC of clinical haematology: The future of haematology, molecular biology, and gene therapy

Abc of Clinical Haematology

Clinical applications of molecular haematology: an overview.

Haematological disorders are getting more and more molecularly defined. This is specially so in the field of haematological malignancies. The molecular understanding has helped in fine-tuning the diagnosis, prognosis and management. The tests are becoming widely available and they enjoy both sensitivity and specificity. Following is an overview of clinical applications of molecular haematology,...

Clinical applications of molecular haematology: JAK2 in myeloproliferative disorders.

Molecular markers are helpful in diagnosis, prognosis and management of haematological malignancies. Recently, a single point mutation in the Janus Kinase 2 (JAK2) gene in the Philadelphia-negative myeloproliferative disorders, including polycythemia vera (over 95%), essential thrombocythemia (50%) and primary myelofibrosis (50%) was identified by several groups. This mutation is now considered...

Haematology in Tropical Areas: Clinics in Haematology

CLINICS in Haematology were introduced some 10 years ago to provide in depth reviews of different aspects of the discipline and have become an accepted and highly respected part of haematology literature. To mark the 10th anniversary there has been a break from tradition and rather than dealing with a specialised topic, the present issue is devoted to Haematology in Tropical Areas. That the spe...

The Feulgen Reaction Applied to Clinical Haematology.

The Feulgen reaction is a cytochemical test for the detection of desoxyribonucleic (tliymonucleic) acid. After acid hydrolysis, desoxyribonucleic acid in the presence of sulphurous acid gives a characteristic red-purple colour with basic fuchsin, and the depth of the colour roughly reflects the concentration of the compound. The detailed chemistry of the reaction has been fully described by Bak...